Hydrochloric Acid → HCID 16064795, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 68 (78 mg, 0.163 mmol), 10% aq. HCl (1.0 mL), EtOH (1.0 mL) was heated at 90° C. for 14 h. Purification by PTLC using AcOEt as eluent gave 69 as a white solid (22.8 mg, 40%); 1H NMR (400 MHz, CDCl3) δ 2.70 (s, 6H), 3.79 (s, 3H), 7.26 (m, 1H), 6.34 (ddd, J=8.3, 2.5, 0.7 Hz, 1H), 6.44 (t, J=2.1 Hz, 1H), 6.91 (t, J=8.0 Hz, 1H), 7.26 (s, 1H), 7.45 (s, 1H), 7.55 (d, J=0.7 Hz, 1H), 8.10 (d, J=2.0 Hz, 1H), 8.28 (d, J=1.9 Hz, 1H).

Provenance & Evidence