5,6,7,8-Tetrahydro-1-naphthol → (5,6,7,8-Tetrahydro-naphthalen-1-yloxy)-acetic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH3:13])[CH3:2].[C:15]1(O)[C:24]2CCCCC=2C=C[CH:16]=1>>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][O:6][C:7]1[C:8]2[CH2:13][CH2:24][CH2:15][CH2:16][C:9]=2[CH:10]=[CH:11][CH:12]=1)[CH3:2]Participants
3
Procedure
The title compound was prepared according to the method described for preparing compound 10.1, using 5,6,7,8-tetrahydro-1-naphthol as the starting material. 1H NMR (300 MHz) (CDCl3) δ 7.02 (1H, t, J=7.7 Hz); 6.73 (1H, d, J=7.3 Hz); 6.51 (1H, d, J=8.1 Hz); 4.61 (2H, s); 4.26 (2H, q, J=7.3 Hz); 2.77-2.73 (4H, m); 1.81-1.76 (4H, m); 1.30 (3H, t, J=7.3 Hz).
Sources & evidence
- ORD record
- ord-f3b6231629d4432ea8374127e804395b
- Source dataset
- uspto-grants-2010_01
- Patent number
- US07645779B2
Reaction notes
Loading…