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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1991175Generated: October 31, 2026

4-[[2-Chloro-4-[(4-trifluoromethylphenoxy)methyl]phenyl]sulfanyl]-2-methylphenoxy-acetic acid ethyl ester → {4-[2-Chloro-4-(4-trifluoromethyl-phenoxymethyl)-phenylsulfanyl]-5,6,7,8-tetrahydro-naphthalen-1-yloxy}-acetic acid ethyl ester

https://huagongshe.com/reaction/1991175

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-[[2-Chloro-4-[(4-trifluoromethylphenoxy)methyl]phenyl]sulfanyl]-2-methylphenoxy-acetic acid ethyl esterHCID 20768114—
Reactant[4-(2-Chloro-4-hydroxymethyl-phenylsulfanyl)-5,6,7,8-tetrahydro-naphthalen-1-yloxy]-acetic acid ethyl esterHCID 20768128—
Product{4-[2-Chloro-4-(4-trifluoromethyl-phenoxymethyl)-phenylsulfanyl]-5,6,7,8-tetrahydro-naphthalen-1-yloxy}-acetic acid ethyl esterHCID 20768125—

Reaction Steps

The title compound was prepared according to the method described for preparing compound 10.6, using compound 23.1 as the starting material. 1H NMR (400 MHz) (CDCl3) δ 7.54 (2H, d, J=8.7 Hz); 7.42 (1H, d, J=1.7 Hz); 7.37 (1H, d, J=8.5 Hz); 7.06 (1H, dd, J=1.8, 8.2 Hz); 6.99 (2H, d, J=8.7 Hz); 6.59 (1H, d, J=8.5 Hz); 6.52 (1H, d, J=8.2 Hz); 4.99 (2H, s); 4.68 (2H, s); 4.29 (2H, q, J=7.1 Hz); 2.80-2.73 (4H, m); 1.76-1.70 (4H, m); 1.32 (3H, t, J=7.2 Hz).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07645779B2
Source datasetuspto-grants-2010_01
ORD IDord-fd6b73cd28c348659b811fb4ef17feeb
Source noteuspto-grants-2010_01