HCID 11391466, compound → HCID 11413680, compound

Participants

Reaction Steps

A solution of ethyl N-formyl-N-(2-methyl-6-nitrophenyl)glycinate (154 mg, 0.58 mmol) in methanol containing 5% Pd/C (35 mg) was hydrogenated at 1 atmosphere for 1 h. The mixture was filtered through a pad of celite, and the solvent was removed in vacuo affording ethyl N-(2-amino-6-methylphenyl)-N-formylglycinate, 127 mg (93%) as an oil. MS (ESI) m/z 237 [M+H]. 1H NMR (400 MHz, CDCl3) δ ppm 1.30 (t, J=7.2Hz, 3H), 2.14 (s, 3H), 3.60 (d, J=17 Hz, 1H), 4.32-4.18 (m, 2H), 4.70 (br. s, 2 H), 4.77 (d, J=17 Hz, 1H), 6.60 (app t, J=8.0 Hz, 2H), 7.05 (t, J=7.8 Hz, 1H), 8.11 (s,

Provenance & Evidence