HCID 11380547, compound → HCID 11312262, compound

HRID 1991196Notes

Reaction equation

HRID 1991196 reaction equation
CN(C)S(C1C2[N:12]([CH2:15][C:16](O)=[O:17])C=NC=2C=CC=1)(=O)=O.Cl[C:21]1[C:26]([S:27]([CH2:30][CH2:31][CH3:32])(=[O:29])=[O:28])=[CH:25][CH:24]=[CH:23][C:22]=1[N+:33]([O-:35])=[O:34]>>[N+:33]([C:22]1[CH:23]=[CH:24][CH:25]=[C:26]([S:27]([CH2:30][CH2:31][CH3:32])(=[O:29])=[O:28])[C:21]=1[NH:12][CH2:15][CH2:16][OH:17])([O-:35])=[O:34]

Participants

3

Reactant 2

HCID 11380547HCID 11380547, compoundHCID 11459724HCID 11459724, compound

Product 1

HCID 11312262HCID 11312262, compoundYield 99%

Procedure

The compound was synthesized in 99% yield according to the procedure described for the synthesis of (7-dimethylsulfamoyl-benzoimidazol-1-yl)-acetic acid, part B, starting from 2-chloro-1-nitro-3-(propylsulfonyl)benzene. MS (ESI) m/z 289 [M+H]. 1H NMR (400 MHz, CDCl3) δ ppm 1.02 (t, J=7.4 Hz, 3H), 1.80-1.70 (m, 3H), 3.13-3.09 (m, 2H), 3.27-3.23 (m, 2H), 3.87-3.84 (m, 2H), 6.88 (t, J=8.0 Hz, 1H), 6.95 (broad s, 1H), 7.91 (dd, J=8.1, 1.5 Hz, 1H), 7.99 (dd, J=7.8, 1.8 Hz, 1H).

Workup

  1. customThe compound was synthesized in 99% yield

Sources & evidence

ORD record
ord-9385f93794da42a48cd286fe80b62c61
Source dataset
uspto-grants-2010_01
Patent number
US07645784B2

Reaction notes

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