HCID 11219784, compound → HCID 11253458, compound

HRID 1991198Notes

Reaction equation

HRID 1991198 reaction equation
[CH2:1]([S:4]([C:7]1[C:12]2[N:13]([CH2:16][C:17](O)=[O:18])[CH:14]=[N:15][C:11]=2[CH:10]=[CH:9][CH:8]=1)(=[O:6])=[O:5])CC.ClC1C(SC)=CC=CC=1[N+]([O-])=O>>[CH3:1][S:4]([C:7]1[C:12]2[N:13]([CH2:16][CH2:17][OH:18])[CH:14]=[N:15][C:11]=2[CH:10]=[CH:9][CH:8]=1)(=[O:5])=[O:6]

Participants

3

Reactant 2

HCID 11219784HCID 11219784, compoundHCID 68491001HCID 68491001, compound

Product 1

HCID 11253458HCID 11253458, compound

Procedure

This compound was synthesized according to the procedure described for the synthesis of [7-(propylsulfonyl)-1H-benzimidazol-1-yl]acetic acid starting from 2-chloro-1-nitro-3-(methylthio)benzene. MS (ESI) m/z 241 [M+H]. 1H NMR (400 MHz, DMSO-D6) δ 8.39 (s, 1H), 8.05 (dd, J=8.1, 1.0 Hz, 1H), 7.86 (dd, J=7.8, 1.0 Hz, 1H), 7.42 (t, J=8.0 Hz, 1H), 5.01 (t, J=5.1 Hz, 1H), 4.71 (t, J=5.2 Hz, 2H), 3.79-3.76 (m, 2H), 3.46 (s, 3H).

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-dc3fbcff5f384dfa9ffd544456b058c5
Source dataset
uspto-grants-2010_01
Patent number
US07645784B2

Reaction notes

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