反应详情

温度

60 °C

To a solution of 2-{[2-nitro-6-(trifluoromethyl)phenyl]amino}ethanol (0.72 g, 2.88 mmol) in methanol (30 mL) a suspension of 85% sodium hydrosulfite (2.0 g, 9.8 mmol) in water (6 mL) was added. Additional water (4 mL) was added, and the mixture was heated at 60° C. for 15 min. The reaction mixture was cooled and concentrated in vacuo. The residue was extracted with ethyl acetate, and the organic phase was dried over magnesium sulfate. The solvent was removed in vacuo affording 0.57 g of 2-{[2-amino-6-(trifluoromethyl)phenyl]amino}ethanol: MS (ES) m/z 219 [M−H].

1. additionwas added
2. temperatureThe reaction mixture was cooled
3. concentrationconcentrated in vacuo
4. extractionThe residue was extracted with ethyl acetate
5. dry with materialthe organic phase was dried over magnesium sulfate
6. customThe solvent was removed in vacuo