反应详情

(7-Cyano-1H-benzimidazol-1-yl)acetic acid was prepared starting from 1-(2-hydroxyethyl)-1H-benzimidazole-7-carbonitrile (89 mg) according to the procedure described for the synthesis of (7-bromo-1H-benzoimidazol-1-yl)acetic acid. Yield 38 mg (39 %). MS (ESI) m/z 202.0 [M+H). 1H NMR (400 MHz, DMSO-D6) δ ppm: 5.31 (s, 2 H), 7.37 (dd, J=8.1, 7.7 Hz, 1H), 7.75 (dd, J=7.6, 0.8 Hz, 1H), 8.04 (dd, J=8.1, 1.1 Hz, 1H), 8.38 (s, 1H), 13.43 (bs, 1H).