HCID 11245451, compound → HCID 11450452, compound

Participants

Reaction Steps

To a solution of 2-(7-nitro-1H-benzoimidazol-1-yl)-N-[3-(trifluoromethyl)phenyl]acetamide, described above, (0.4 g, 1.1 mmol) in methanol (15 mL) 10% Pd/C (60 mg) was added. The mixture was hydrogenated at atmospheric pressure until the consumption of hydrogen ceased (1 h). The catalyst was removed by filtration through Celite, and the resulting clear solution was concentrated to dryness to yield the title compound, 0.36 g (99%). MS (ESI) m/z: 335.07 [M+H]. 1H NMR (400 MHz, DMSO-D6) δ ppm 4.91 (s, 2H) 5.33 (s, 2H) 6.50 (m, 1H) 6.89 (t, J=7.6 Hz, 1H) 6.97 (m, 1H) 7.41 (d, J=7.6 Hz, 1H) 7.56 (t, J=7.8 Hz, 1H) 7.77 (m, 1H) 7.99 (s, 1H) 8.07 (s, 1H) 10.84 (s, 1H).

Provenance & Evidence