Dimethylformamide → HCID 68488914, compound

Participants

Reaction Steps

To a solution of 2-(7-bromo-1H-benzoimidazol-1-yl)-N-(3,5-dimethoxyphenyl)acetamide (Example 52) (50 mg, 0.13 mmol) in dry DMF (0.64 mL) copper(I) cyanide (23 mg, 0.26 mmol) was added. The mixture was irradiated in a microwave oven at 200° C. for 60 min. The reaction mixture was partitioned between ethyl acetate and water. The organic extract was concentrated and the residue was purified by preparative HPLC to yield the title compound, 20 mg (46%). MS (ESI) m/z: 337.2 [M+H). 1H NMR (400 MHz, DMSO-D6) δ ppm 3.69 (s, 6 H) 5.39 (s, 2H) 6.23 (t, J=2.3 Hz, 1H) 6.80 (d, J=2.0 Hz, 2 H) 7.37 (t, J=7.8 Hz, 1H) 7.74 (d, J=7.1 Hz, 1H) 8.05 (dd, J=8.1, 1.0 Hz, 1H) 8.40 (s, 1H) 10.47 (s, 1H).

Provenance & Evidence