3,4-Difluoroaniline → 2-(1H-Benzo[d]imidazol-1-yl)-N-(3,4-difluorophenyl)acetamide

HRID 1991215Notes

Reaction equation

HRID 1991215 reaction equation
FC(F)(F)C([O-])=O.[C:8]([CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[NH+:14]=[CH:13]1)([OH:10])=O.[F:21][C:22]1[CH:23]=[C:24]([CH:26]=[CH:27][C:28]=1[F:29])[NH2:25]>>[N:12]1([CH2:11][C:8]([NH:25][C:24]2[CH:26]=[CH:27][C:28]([F:29])=[C:22]([F:21])[CH:23]=2)=[O:10])[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 774693,4-DifluoroanilineHCID 1785258373-carboxymethyl-3H-benzoimidazol-1-ium trifluoro-acetate

Product 1

HCID 35781692-(1H-Benzo[d]imidazol-1-yl)-N-(3,4-difluorophenyl)acetamide

Procedure

The title compound was synthesised according to the procedure described in Example 92, from 3-carboxymethyl-3H-benzoimidazol-1-ium trifluoro-acetate and 3,4-difluoroaniline Yield 9.1 mg (26%). Calculated for C15H11F2N3O m/z: 287.2, found 288.3 [M+H]+. 1H NMR (400 MD, MeOD) δ ppm 5.2 (s, 2H), 7.3 (m, 4 H), 7.5 (d, J=7.1 Hz, 1H), 7.7 (m, 2H),8.2(s, 1H).

Sources & evidence

ORD record
ord-fe631ce3a0254622b12f339a8364bb8b
Source dataset
uspto-grants-2010_01
Patent number
US07645784B2

Reaction notes

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