4-Chlorobenzylamine → 2-(1H-Benzimidazol-1-yl)-N-(4-chlorobenzyl)acetamide

HRID 1991220Notes

Reaction equation

HRID 1991220 reaction equation
FC(F)(F)C([O-])=O.[C:8]([CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[NH+:14]=[CH:13]1)([OH:10])=O.[Cl:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH2:27])=[CH:24][CH:23]=1>>[N:12]1([CH2:11][C:8]([NH:27][CH2:26][C:25]2[CH:28]=[CH:29][C:22]([Cl:21])=[CH:23][CH:24]=2)=[O:10])[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 660364-ChlorobenzylamineHCID 1785258373-carboxymethyl-3H-benzoimidazol-1-ium trifluoro-acetate

Product 1

HCID 163142322-(1H-Benzimidazol-1-yl)-N-(4-chlorobenzyl)acetamide

Procedure

The title compound was synthesized according to a procedure described in Example 98 starting from 3-carboxymethyl-3H-benzoimidazol-1-ium trifluoro-acetate (Example 92, Part B) and 4-chloro-benzylamine. Calculated for C16H14ClN3O m/z: 299.76, found 301.1 [M+H]+.

Sources & evidence

ORD record
ord-3fedd9a2cb3d49a5ac613263d2b76748
Source dataset
uspto-grants-2010_01
Patent number
US07645784B2

Reaction notes

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