HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoromethanesulfonic acid, lithium salt → methyl (2R)-3-[(3-ethyl-4-fluoro-2-oxo-2,3-dihydro-6-benzoxazolyl)amino]-2-hydroxypropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoromethanesulfonic acid, lithium salt | HCID 3664839 | — |
| Reactant | Methyl (2R)-2-oxiranecarboxylate | HCID 9877347 | — |
| Reactant | 6-amino-3-ethyl-4-fluoro-1,3-benzoxazol-2(3H)-one | HCID 68490571 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | methyl (2R)-3-[(3-ethyl-4-fluoro-2-oxo-2,3-dihydro-6-benzoxazolyl)amino]-2-hydroxypropanoate | HCID 86610081 | — |
Reaction Steps
Prepared from 6-amino-3-ethyl-4-fluoro-1,3-benzoxazol-2(3H)-one (Step 2, 0.90 g, 4.59 mmol), methyl (2R)-glycidate (0.469 g, 4.59 mmol) and lithium trifluoromethanesulfonate (0.716 g, 4.59 mmol) in acetonitrile (10 ml) according to the method of EXAMPLE 86, Step 8 (1.11 g, 81%); MS for C13H15FN2O5 m/z 299 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07645781B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-a09fafc7915441bab831681899c4cc6d |
| Source note | uspto-grants-2010_01 |