HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → 4-fluoro-3-isopropyl-6-nitro-1,3-benzoxazol-2(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 4-fluoro-6-nitro-1,3-benzoxazol-2(3H)-one | HCID 68489292 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-fluoro-3-isopropyl-6-nitro-1,3-benzoxazol-2(3H)-one | HCID 68487872 | — |
Reaction Steps
Prepared from 2-iodopropane (0.76 ml, 7.57 mmol), 4-fluoro-6-nitro-1,3-benzoxazol-2(3H)-one (EXAMPLE 86, Step 5, 1.2 g, 6.06 mmol) and 1,8-diazabicyclo[5.4.0]undec-7-ene (1.13 ml, 7.57 mmol) in DMF (10 ml) according to the method of EXAMPLE 86, Step 6 (0.87 g, 60%); mp 122-3° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07645781B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-57275d39f26d4c4783a92f55f03f9918 |
| Source note | uspto-grants-2010_01 |