1,2,4-Cyclopentanetrione → HCID 86599802, compound

HRID 1991366Notes

Reaction equation

HRID 1991366 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([C@H:13]([O:15][C@H:16]2[CH2:24][CH2:23][C@H:22]3[C@@H:18]([CH2:19][NH:20][CH2:21]3)[C@@H:17]2[C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[CH3:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[C:34]1(=O)[CH2:38][C:37](=[O:39])[CH2:36][C:35]1=[O:40]>>[F:33][C:2]([F:1])([F:32])[C:3]1[CH:4]=[C:5]([C@H:13]([O:15][C@H:16]2[CH2:24][CH2:23][C@H:22]3[C@@H:18]([CH2:19][N:20]([C:34]4[C:35](=[O:40])[CH2:36][C:37](=[O:39])[CH:38]=4)[CH2:21]3)[C@@H:17]2[C:25]2[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=2)[CH3:14])[CH:6]=[C:7]([C:9]([F:12])([F:10])[F:11])[CH:8]=1

Participants

3

Reactant 2

HCID 275071,2,4-CyclopentanetrioneHCID 24993312HCID 24993312, compound

Product 1

HCID 86599802HCID 86599802, compound

Procedure

The title compound was prepared from (3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-bis(tri-fluoromethyl)Phenyl]ethoxy}-4-(4-fluorophenyl)octahydro-1H-isoindole (Example 6) and cyclopentane-1,2,4-trione according to the procedure of Example 7. MS: (MH)+570.0

Sources & evidence

ORD record
ord-d8aec726a08e417fbf953ad7cd7e325b
Source dataset
uspto-grants-2010_01
Patent number
US07645790B2

Reaction notes

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