1,3-Cyclopentanedione → HCID 24993630, compound

Participants

Reaction Steps

The title compound was prepared from (3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-bis(tri-fluoromethyl)phenyl]ethoxy}-4-(2-methylphenyl)octahydro-1H-isoindole (step L) and cyclopentane-1,3-dione according to the procedure of Example 7. 1H-NMR (CDCl3): rotamers δ: 7.64 (1H, s), 7.18 (2H, s), 7.04-6.97 (4H, m), 4.74, 4.53 (1H, s), 4.42 (1H, m), 3.68, 3.43 (1H, m), 3.50 (1H, m), 3.06 (1H, m), 2.93 (2H, m), 2.86, 2.76 (1H, m), 2.57 (1H, m), 2.40 (2H, m), 2.28 (3H, s), 2.20 (1H, m), 2.17 (1H, m), 2.10-1.94 (3H, m), 1.58 (1H, m), 1.40 (1H, m), 1.28 (3H, d, J=6.0 Hz). MS: (MH)+552.43

Provenance & Evidence