Bromine → 395-15-3

HRID 1991393Notes

Reaction equation

HRID 1991393 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3](=[O:11])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[Br:14]Br>C(OCC)C>[Br:14][CH:4]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[C:3](=[O:11])[C:2]([F:12])([F:13])[F:1]

Participants

4

Reactant 2

HCID 24408BromineHCID 2229581,1,1-Trifluoro-3-phenyl-2-propanone

Product 1

HCID 14026649395-15-3

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
0 °C

Procedure

1,1,1-trifluoro-3-phenylpropanone (0.50 mL, 3.2 mmol) was dissolved in 5 mL of diethyl ether and the mixture was cooled to 0° C. Bromine (0.16 mL, 3.2 mmoL) was added and the mixture was stirred for 18 h and allowed to warm to rt. The solvent was removed to provide a 2:1 mixture of Example A176a as a starting material which was used in the subsequent reaction without further purification.

Workup

  1. temperatureto warm to rt
  2. customThe solvent was removed
  3. customto provide
  4. customwas used in the subsequent reaction without further purification

Sources & evidence

ORD record
ord-14a051ada12c43c09ee217d510250ce9
Source dataset
uspto-grants-2010_01
Patent number
US07645778B2

Reaction notes

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