Ammonium Chloride → HCID 68688833, compound

HRID 1991405Notes

Reaction equation

HRID 1991405 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[N:14]=[C:13]([C@H:15]3[CH2:20][CH2:19][CH2:18][CH2:17][N:16]3[C:21](=[O:30])[CH2:22][O:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[O:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O.[NH4+].[Cl-]>CO.[Zn]>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[N:14]=[C:13]([C@H:15]3[CH2:20][CH2:19][CH2:18][CH2:17][N:16]3[C:21](=[O:30])[CH2:22][O:23][C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[O:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 25517Ammonium ChlorideHCID 16737888HCID 16737888, compound

Product 1

HCID 68688833HCID 68688833, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 887MethanolSolvent

Procedure

(R)-1-{2-[3-(3-Nitro-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-2-phenoxy-ethanone were dissolved in 100 ml MeOH. 50 ml sat. NH4Cl and Zn-powder were added. The suspension was briefly heated to reflux and stirred for 30 min. After filtration the MeOH was evaporated and the product isolated via extraction ethylacetate/water.

Workup

  1. temperatureThe suspension was briefly heated
  2. temperatureto reflux
  3. filtrationAfter filtration the MeOH
  4. customwas evaporated
  5. customthe product isolated via extraction ethylacetate/water

Sources & evidence

ORD record
ord-bb6a119d40fb4f4dbd9844b7648773bc
Source dataset
uspto-grants-2010_01
Patent number
US07645776B2

Reaction notes

Loading…