Ammonium Chloride → HCID 68687135, compound

HRID 1991407Notes

Reaction equation

HRID 1991407 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[N:11]=[C:12]([C@H:15]3[CH2:20][CH2:19][CH2:18][CH2:17][N:16]3[C:21](=[O:30])[CH2:22][O:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[NH:13][N:14]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O.[NH4+].[Cl-]>CO.[Zn]>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[N:11]=[C:12]([C@H:15]3[CH2:20][CH2:19][CH2:18][CH2:17][N:16]3[C:21](=[O:30])[CH2:22][O:23][C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[NH:13][N:14]=2)[CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 25517Ammonium ChlorideHCID 68685639HCID 68685639, compound

Product 1

HCID 68687135HCID 68687135, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 887MethanolSolvent

Procedure

(R)-1-{2-[5-(3-Nitro-phenyl)-2H-[1,2,4]triazol-3-yl]-piperidin-1-yl}-2-phenoxy-ethanone were dissolved in 100 ml MeOH. 50 ml sat. NH4Cl and Zn-powder were added. The suspension was briefly heated to reflux and stirred for 30 min. After filtration the MeOH was evaporated and the product isolated via extraction ethylacetate/water.

Workup

  1. temperatureThe suspension was briefly heated
  2. temperatureto reflux
  3. filtrationAfter filtration the MeOH
  4. customwas evaporated
  5. customthe product isolated via extraction ethylacetate/water

Sources & evidence

ORD record
ord-f7e44bdca0fd4bd4af6b85ed5784d618
Source dataset
uspto-grants-2010_01
Patent number
US07645776B2

Reaction notes

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