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Propanoyl chloride, 3-bromo- → HCID 68688175、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propanoyl chloride, 3-bromo- | HCID 84944 | — |
| 反応物 | 1-{2-[5-(3-Amino-phenyl)-2H-[1,2,4]triazol-3-yl]-piperidin-1-yl}-2-phenoxy-ethanone | HCID 68687138 | — |
| 溶媒 | Diisopropylethylamine | HCID 81531 | — |
| 生成物 | HCID 68688175 | HCID 68688175 | — |
反応手順
75 mg of 1-{2-[5-(3-Amino-phenyl)-2H-[1,2,4]triazol-3-yl]-piperidin-1-yl}-2-phenoxy-ethanone were dissolved in MDF and 40 ul DIPEA added. 34 mg of 3-Bromo-propionyl chloride were added at 0° C. and the reaction warmed up to rt and stirred for another 30 min. The reaction mixture was heated to 120° C. using microwave heating and the product was isolated via preparative HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07645776B2 |
| 出典データセット | uspto-grants-2010_01 |
| ORD ID | ord-aa6e1097c2834c3d944ea2cefe960780 |
| 出典メモ | uspto-grants-2010_01 |