Pyridoxal → HCID 136395568, compound

HRID 1991447Notes

Reaction equation

HRID 1991447 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([CH:10]=O)[C:3]=1[OH:12].C[C:14]1[CH2:18][C:17](=[O:19])[N:16]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:15]=1>>[OH:12][C:3]1[C:2]([CH3:1])=[N:7][CH:6]=[C:5]([CH2:8][OH:9])[C:4]=1[CH:10]=[C:18]1[C:17](=[O:19])[N:16]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[N:15]=[CH:14]1

Participants

3

Reactant 2

HCID 1050Pyridoxal2×HCID 4021Mci-186

Product 1

HCID 136395568HCID 136395568, compound

Procedure

Provided that, the substituent introduced to methylene at 4-position are not always present stably depending on the variation. For example, when to introduce pyridoxal residue to methylen at 4-position, 3-methyl-1-phenyl-2-pyrazolin-5-one is reacted with pyridoxal, then actually obtain not 4-(3-hydroxy-5-hydroxymethyl-2-methylpyridin-4-yl-methylene)-1-phenyl-2-pyrazolin-5-one, but 1-(5-hydroxy-3-methyl-1-phenyl-1H-4-yl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol.

Workup

  1. customProvided that, the
  2. additionsubstituent introduced to methylene at 4-position

Sources & evidence

ORD record
ord-e02b60f1e1d24d3d99a94391ba0860f1
Source dataset
uspto-grants-2010_01
Patent number
US07645882B2

Reaction notes

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