Hydrochloride methanol → HCID 178432457, compound

Participants

Reaction Conditions

Reaction Steps

0.5006 g of 1-(5-hydroxy-3-methyl-1-phenyl-1-H-pyrazol-4-yl)-6-methyl-1,3-dihydro-furo[3,4-c]pyridin-7-ol was solved in 150 mL of methanol, and 2N of methanol hydrochloride (1.65 mL) was added and stirred. The solution was concentrated to about 20 mL, and when crystals were precipitate, 50 mL of ethanol was added and concentrated to substitute the crystal solvent, and continued this operation twice and concentrated to about 5 mL. This concentrated solution was stood to cool in refrigerator (4° C.) overnight, the precipitate was filtered off and dried in vacuum desiccator to give 1-(5-hydroxy-3-methyl-1-phenyl-1-H-pyrazol-4-yl)-6-methyl-1,3-dihydro-furo[3,4-c]pyridin-7-ol hydrochloride (0.5011 g). Yield 90.0%. Appearance: crystal powder, pale yellow white. Melting point: 247-249° C. (browning melt).

Provenance & Evidence