Methanol → Methyl 4-(methylamino)butanoate

HRID 1991590Notes

Reaction equation

HRID 1991590 reaction equation
Cl.[CH3:2][NH:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8].S(Cl)(Cl)=O.[CH3:14]O>>[CH3:14][O:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4][NH:3][CH3:2]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 126266544-(Methylamino)butyric acid hydrochloride

Product 1

HCID 14769104Methyl 4-(methylamino)butanoate

Conditions

Temperature
0 °C

Procedure

4-(methylamino) butyric acid HCl was dissolved in methanol and thionyl chloride in catalytic amount was added drop by drop. The reaction mixture was stirred at 0° C. for 30 min. Thereafter, the solvent was reduced in vacu, yielding a white solid.

Workup

  1. customyielding a white solid

Sources & evidence

ORD record
ord-a3dd38a54c534097bca325db7a81d19e
Source dataset
uspto-grants-2010_01
Patent number
US07645903B2

Reaction notes

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