HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1991917Generated: October 31, 2026
Thionyl Chloride → 3,4-Difluoro-benzoic acid 4-(2-chlorocarbonyl-vinyl)-phenyl ester
https://huagongshe.com/reaction/1991917
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3,4-Difluoro-benzoic acid 4-(2-carboxy-vinyl)-phenyl ester | HCID 68537954 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3,4-Difluoro-benzoic acid 4-(2-chlorocarbonyl-vinyl)-phenyl ester | HCID 72362052 | 90% |
Reaction Steps
About 10 g (about 21.68 mmol) of 3,4-difluoro-benzoic acid 4-(2-carboxy-vinyl)-phenyl ester was dissolved in about 200 ml of methylene chloride, and about 2.84 g (23.848 mmol) of thionyl chloride (SOCl2) was added thereto. Thereafter, the reaction mixture was stirred at about 35° C. for about 6 hours, followed by removing the solvent. Subsequently, a vacuum drying process was conducted, thus obtaining the desired compound (Yield about 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07646014B2 |
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| Source dataset | uspto-grants-2010_01 |
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| ORD ID | ord-72af5323641546aea381b79ab4b5cbc8 |
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| Source note | uspto-grants-2010_01 |
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