2,2,2-Trifluoro-N-(pyrrolidin-3-YL)acetamide → N-(1-{5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-pyrrolidin-3-yl)-2,2,2-trifluoro-acetamide

HRID 199192Notes

Reaction equation

HRID 199192 reaction equation
[Cl:1][c:2]1[cH:3][c:4]([C:27]([F:28])([F:29])[F:30])[c:5]([CH2:6][n:7]2[n:8][cH:9][c:10]3[cH:11][c:12]([CH:16]=[C:17]4[C:18](=[O:24])[N:19]=[C:20]([S:22][CH3:23])[S:21]4)[cH:13][cH:14][c:15]23)[cH:25][cH:26]1.[F:31][C:32]([C:33](=[O:34])[NH:35][CH:36]1[CH2:37][NH:38][CH2:39][CH2:40]1)([F:41])[F:42]>>[Cl:1][c:2]1[cH:3][c:4]([C:27]([F:28])([F:29])[F:30])[c:5]([CH2:6][n:7]2[n:8][cH:9][c:10]3[cH:11][c:12]([CH:16]=[C:17]4[C:18](=[O:24])[N:19]=[C:20]([N:38]5[CH2:37][CH:36]([NH:35][C:33]([C:32]([F:31])([F:41])[F:42])=[O:34])[CH2:40][CH2:39]5)[S:21]4)[cH:13][cH:14][c:15]23)[cH:25][cH:26]1

Participants

3

Reactant 2

HCID 5375752,2,2-Trifluoro-N-(pyrrolidin-3-YL)acetamideHCID 672400965-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one

Product 1

HCID 76756436N-(1-{5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-pyrrolidin-3-yl)-2,2,2-trifluoro-acetamide

Sources & evidence

ORD record
ord-81652af1ba5f46b88eaacf77edaf7319
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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