1-Methyl-2-imidazolecarboxaldehyde → HCID 178480584, compound

HRID 1991958Notes

Reaction equation

HRID 1991958 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:8]1([C:13]2[CH:18]=[C:17]([CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[CH:16]=[CH:15][C:14]=2[NH:25][C:26]([C:28]2[NH:29][CH:30]=[C:31]([C:33]#[N:34])[N:32]=2)=[O:27])[CH2:12][CH2:11][CH2:10][CH:9]=1.[CH3:35][N:36]1[CH:40]=[CH:39][N:38]=[C:37]1[CH:41]=O>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:8]1([C:13]2[CH:18]=[C:17]([CH:19]3[CH2:24][CH2:23][N:22]([CH2:41][C:37]4[N:36]([CH3:35])[CH:40]=[CH:39][N:38]=4)[CH2:21][CH2:20]3)[CH:16]=[CH:15][C:14]=2[NH:25][C:26]([C:28]2[NH:29][CH:30]=[C:31]([C:33]#[N:34])[N:32]=2)=[O:27])[CH2:12][CH2:11][CH2:10][CH:9]=1

Participants

3

Reactant 2

HCID 1395751-Methyl-2-imidazolecarboxaldehydeHCID 178510381HCID 178510381, compound

Product 1

HCID 178480584HCID 178480584, compound

Procedure

This compound was prepared from 4-cyano-1H-imidazole-2-carboxylic acid (2-cyclopent-1-enyl-4-piperidin-4-yl-phenyl)-amide TFA salt (as prepared in Example 18) and 1-methyl-1H-imidazole-2-carbaldehyde according to the procedure in Example 21. 1H-NMR (400 MHz, CD3OD): δ 8.03 (m, 2H), 7.50 (d, 1H), 7.42 (s, 1H), 7.20 (m, 2H), 6.02 (m, 1H), 4.22 (s, 2H), 3.96 (s, 3H), 3.30 (m, 2H), 2.82-2.40 (m, 7H), 2.13-1.84 (m, 6H). Mass spectrum (ESI, m/z): Calcd. for C26H29N7O, 456.2 (M+H), found 456.2.

Sources & evidence

ORD record
ord-bbc7962136124db0b9b89905d1226a13
Source dataset
uspto-grants-2010_01
Patent number
US07645755B2

Reaction notes

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