Potassium Hydroxide → HCID 68451726, compound

HRID 1991995Notes

Reaction equation

HRID 1991995 reaction equation
C[O:2][C:3]([C:5]1[N:9]=[CH:8][N:7]([CH2:10][O:11][CH2:12][CH2:13][Si:14]([CH3:17])([CH3:16])[CH3:15])[N:6]=1)=[O:4].[OH-].[K+:19]>CCO.CCOCC>[K+:19].[CH3:15][Si:14]([CH3:17])([CH3:16])[CH2:13][CH2:12][O:11][CH2:10][N:7]1[CH:8]=[N:9][C:5]([C:3]([O-:4])=[O:2])=[N:6]1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 59128601HCID 59128601, compound

Product 1

HCID 68451726HCID 68451726, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of 1-(2-trimethylsilanyl-ethoxymethyl)-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester (as prepared in the previous step, 257 mg, 1.00 mmol) in EtOH (2 mL), 2 N KOH (0.5 mL, 1 mmol) was added. The resulting solution was stirred at RT for 20 min and concentrated in vacuo. The residue obtained was suspended in ether (10 mL) and sonicated for 5 min. The ether was then removed in vacuo and the resulting residue was dried for 4 hr to obtain 1-(2-trimethylsilanyl-ethoxymethyl)-1H-[1,2,4]-triazole-3-carboxylic acid potassium salt (273 mg, 97%) which was directly used in the next step without any further purification.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe residue obtained
  3. customsonicated for 5 min
  4. customThe ether was then removed in vacuo
  5. customthe resulting residue was dried for 4 hr

Sources & evidence

ORD record
ord-3da2a0e1d54d4286b29e3c0b0906898b
Source dataset
uspto-grants-2010_01
Patent number
US07645755B2

Reaction notes

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