2,6-Dichlorobenzoic acid → 2,6-Dichloro-3-(chlorosulfonyl)benzoic acid

Participants

Reaction Conditions

Reaction Steps

Chlorosulfonic acid was slowly added to 2,6-dichlorobenzoic acid at RT under N2. The reaction was heated to 150° C. for 3 h, then slowly poured over ice and the product extracted into Et2O. The organic layer was dried over MgSO4, filtered and concentrated to give 2,6-dichloro-3-(chlorosulfonyl)benzoic acid 880-1a as a brown solid (12.9 g, 85% yield).

Provenance & Evidence