HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoic acid, 2-chloro-5-(chlorosulfonyl)- → 5-(Tert-butylsulfamoyl)-2-chlorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoic acid, 2-chloro-5-(chlorosulfonyl)- | HCID 67306 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,6-Dichloro-3-(methylsulfamoyl)benzoic acid | HCID 29039908 | — |
| Product | 5-(Tert-butylsulfamoyl)-2-chlorobenzoic acid | HCID 25755921 | — |
Reaction Steps
Prepared from a mixture of 2-chloro-5-(chlorosulfonyl)benzoic acid (200 mg, 0.78 mmol, 1 equiv) tert-butyl amine (98 μL, 0.94 mmol, 1.2 equiv) and DIEA (248 μL, 1.38 mmol, 2 equiv) following the general procedure for 2,6-dichloro-3-[(methylamino)sulfonyl]benzoic acid 881-1b. The crude reaction mixture was carried on without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07645771B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-87a6f4cd385d493ab034a8d2ac9e5268 |
| Source note | uspto-grants-2010_01 |