HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → 5-{[(1,1-Dimethylethyl)amino]sulfonyl}-2,4-difluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-(Chlorosulfonyl)-2,4-difluorobenzoic acid | HCID 10753596 | — |
| Reactant | 2,6-Dichloro-3-(methylsulfamoyl)benzoic acid | HCID 29039908 | — |
| Product | 5-{[(1,1-Dimethylethyl)amino]sulfonyl}-2,4-difluorobenzoic acid | HCID 16776416 | — |
Reaction Steps
Prepared from a mixture of 5-(chlorosulfonyl)-2,4-difluorobenzoic acid (200 mg, 0.78 mmol, 1 equiv), tert-butyl amine (98 mL, 0.94 mmol, 1.2 equiv) and DIEA (280 μL, 1.56 mmol, 2 equiv) following the general procedure for 2,6-dichloro-3-[(methylamino)sulfonyl]benzoic acid 880-1b. The crude reaction mixture was carried on without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07645771B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-7f50573748d14f9ea20e5023719e931f |
| Source note | uspto-grants-2010_01 |