HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-aminobenzoate → Methyl 4-methanesulfonamidobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-aminobenzoate | HCID 12082 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | N,N-Diethyl-2-propanamine | HCID 521913 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 4-methanesulfonamidobenzoate | HCID 669159 | — |
Reaction Steps
1.13 g (7.48 mmol) of methyl 4-aminobenzoate was dissolved in 20 mL of anhydrous DCM and 1.97 g (17.19 mmol) of mesyl chloride was added at 4 deg C., followed by the 2.22 g (17.19 mmol) of the diethylisopropylamine. Reaction was carried out overnight at room temperature resulting methyl 4-[(methylsulfonyl)amino]benzoate, which was used in the next step without additional purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07645771B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-7f5f7b731cca4810b466e6e67807f8d0 |
| Source note | uspto-grants-2010_01 |