Chlorotrimethylsilane → HCID 68539762, compound

Participants

Reaction Steps

To a stirred solution of 2,4-dimethyl phenol (5.47 g, 44.8 mmol) in dry dichloromethane (120 ml) at 0° C. under nitrogen was added triethylamine (1.1 eq., 4.99 g, 6.9 ml) followed by the slow addition of trimethyl silyl chloride (1.05 eq., 5.11 g, 6.00 ml). The reaction was monitored by thin layer chromatography (10% ethyl acetate in 60-80 light petroleum) and upon completion (˜2 hr) water (50 ml) was added. The organic layer was washed with water (2×50 ml), dried (Na2SO4), filtered and the solvent removed to give the title compound (8.13 g, 93%).

Provenance & Evidence