HCID 59130267, compound → HCID 59130270, compound

Participants

Reaction Steps

To a solution of 1,1-dimethylethyl [3-(phenylmethyl)-8-oxa-3-azabicyclo[3.2.1]oct-6-yl]carbamate (560 mg, 1.76 mmol) in EtOH (18 mL) at 25° C. was added Pd(OH)2 (336 mg, 60 wt %). The suspension was hydrogenated at 50 psi using a Parr Shaker. After 12 h, the solution was filtered through Celite®, concentrated and purified through a pad of silica (5% MeOH in DCM (1% NH4OH)) affording the title compound (400 mg, quant.) as a white solid: LC/MS (ES) m/e 229 (M+H)+.

Provenance & Evidence