HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → HCID 57948967, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Dimethylethylamine | HCID 11723 | — |
| Reactant | HCID 57627869 | HCID 57627869 | — |
| Product | HCID 57948967 | HCID 57948967 | 35% |
Reaction Steps
4-(3-bromo-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]thiazin-2-ylamine (20 g, 61 mmole) is purified by HPLC chiral separation [Column: 8×32 cm chiralpak AD; Eluent: 60:40:0.2 (isopropyl alcohol: heptanes: dimethylethylamine); Flow: 350 mL/min at UV 260 nm]. The second eluting isomer is isolated to provide the enantiomerically enriched title compound (35% Yield): MS (m/z): 327, 329 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07648983B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-f9955387c9a24d5b83c755150348ae30 |
| Source note | uspto-grants-2010_01 |