Trifluoroacetic acid → HCID 57948959, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-tert-butyl 4-(3-bromo-4-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-ylcarbamate (1.1 g, 2.7 mmoles) and methanol (10 mL) is added trifluoroacetic acid (10 mL). The reaction mixture is warmed to 60° C. After 15 h, the solvent is removed under reduced pressure. Water is added to the resulting residue and the mixture is made basic with saturated sodium bicarbonate. The basic aqueous phase is extracted with dichloromethane. The organic phase is separated, dried over sodium sulfate, filtered, and the solvent removed under reduced pressure to give the title compound (62% yield): MS (m/z): 303, 305 (M+1).

Provenance & Evidence