Water → HCID 68539553, compound

Participants

Reaction Steps

To a solution of (S)-4-(3-bromo-4-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine (550 mg, 1.8 mmoles, 1.0 equiv) in tetrahydrofuran (20 mL) is added pyridine (720 mg, 9.0 mmoles, 5 equiv) and acetic acid anhydride (220 mg, 2.2 mmoles, 1.2 equiv). After 10 minutes, the reaction is poured into water and the aqueous mixture is extracted with dichloromethane. The organic phase is separated and washed with 1N HCl and saturated aqueous NaCl, dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give the title compound (83% yield): MS (m/z) 345, 347 (M+1).

Provenance & Evidence