Dichloromethane → HCID 57948923, compound

Participants

Reaction Steps

To a solution of (S)-2-(3-bromo-4-fluorophenyl)-4-methylpent-4-en-2-amine (1.3 g, 4.6 mmoles, 1.0 equiv) in THF (5 mL) is added benzoyl isothiocyanate (0.63 mL, 4.6 mmoles, 1 equiv). The reaction is stirred at room temperature for 3 h. The solvent is removed under reduced pressure and the residue is purified by silica gel chromatography eluting with a linear gradient of 20% dichloromethane: hexanes to 50% dichloromethane: hexanes to give the title compound (84% yield): MS (m/z): 457, 459 (M+23).

Provenance & Evidence