Tributylstannane → HCID 57948925, compound

Participants

Reaction Steps

To a solution of N-((4S)-4-(3-bromo-4-fluorophenyl)-6-(iodomethyl)-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide (0.13 g, 0.23 mmoles, 1.0 equiv) in toluene (1.5 mL) is added 2-2′-azo-bis-isobutyronitrile (0.006 g, 0.03 mmoles, 0.15 equiv) and tri-n-butyltin hydride. The reaction mixture is stirred at room temperature for 3 h and concentrated under reduced pressure. The solvent is removed under reduced pressure and the residue is purified by silica gel chromatography eluting with a linear gradient of 5% ethyl acetate:hexanes to 20% ethyl acetate:hexanes to give the title compound (25% yield): MS (m/z): 435, 437 (M+1).

Provenance & Evidence