HCID 86635614, compound → HCID 57948942, compound

Participants

Reaction Steps

To a −78° C. solution of (S)-3-(3-bromo-phenyl)-N-methoxy-N-methyl-3-(R)-(2-methyl-propane-2-sulfinylamino)-butyramide (1.5 g, 3.7 mmoles; 1.0 equiv) in THF (53 mL) is added methylmagnesium bromide (6.2 mL, 18.5 mmoles, 5.0 equiv) and the reaction is allowed to warmed to ambient temperature. After 1 h, the reaction is cooled to −78° C. and quenched with saturated aqueous ammonium chloride. The mixture is diluted with water and extracted with ethyl acetate. The organic phase is dried over sodium sulfate, filtered, and concentrated under reduced pressure to give the title compound (>95% yield): MS (m/z) 360, 362 (M+1)

Provenance & Evidence