Hydrochloric Acid → (4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Participants

Reaction Steps

Into a solution of (S)-[4-(2,4-difluoro-5-pyrimidin-5-yl-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]thiazin-2-yl]-carbamic acid tert-butyl ester (263 mg, 625 μmoles) in dichloromethane (15 mL) at ambient temperature is bubbled HCl gas for 1 minute. The reaction is sealed with a septum and stirred 18 h. The solvent is removed under reduced pressure to give the title compound (>95% Yield): MS (m/z): 321 (M+1).

Provenance & Evidence