Ammonia → HCID 59130345, compound

Participants

Reaction Steps

A mixture of 3-[(2-quinoxalinylcarbonyl)amino]-2-thiophenecarboxylic acid (0.70 g, 2.3 mmol), 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (EDC, 2.24 g, 11.5 mmol), and 4-(dimethylamino)pyridine (DMAP, 1.43 g, 11.5 mmol) in CH2Cl2 (100 mL) was stirred at room temperature for 2 h. To the reaction mixture was added aqueous ammonia (40%, 5 mL), and the stirring continued for another 12 h. The solvent was evaporated to dryness and the resulting solid was washed with satd NH4Cl solution (3×), NaHCO3 solution and H2O. The organic phase was evaporated to dryness resulting in a white powder (0.32 g, 46%). HPLC/MS: (M+H)+ 299.4 m/z

Provenance & Evidence