Potassium Carbonate → HCID 9802767, compound

Participants

Reaction Conditions

Reaction Steps

4-[3-(9-Oxa-3,7-diazabicyclo[3.3.1]non-3-yl)propoxy]benzonitrile (6.5 g, 0.0226 mol; see WO 01/28992) and tert-butyl 2-bromoethylcarbamate (6 g, 0.0271 mol; see WO 01/28992) were dissolved in 80 mL of dry acetonitrile. Anhydrous potassium carbonate (4.68 g, 0.034 mol) was added and the mixture was stirred at 60° C. overnight. A further portion of tert-butyl 2-bromoethylcarbamate (2.53 g, 0.0113 mol) was added and the reaction heated at 65° C. overnight. The reaction mixture was then filtered and the filtrate concentrated under reduced pressure. The product was purified by column chromatography using methanol-chloroform as eluent to give the sub-title compound (4.5 g) as a yellow solid.

Provenance & Evidence