Hydrochloric Acid → HCID 131727850, compound

HRID 1992355Notes

Reaction equation

HRID 1992355 reaction equation
C(OC([N:8]1[CH2:15][CH:14]2[O:16][CH:10]([CH2:11][N:12]([CH2:17][CH2:18][N:19]([S:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=3)(=[O:23])=[O:22])[CH3:20])[CH2:13]2)[CH2:9]1)=O)(C)(C)C.[ClH:32]>O1CCOCC1>[ClH:32].[C:30]([C:27]1[CH:28]=[CH:29][C:24]([S:21]([N:19]([CH3:20])[CH2:18][CH2:17][N:12]2[CH2:13][CH:14]3[O:16][CH:10]([CH2:9][NH:8][CH2:15]3)[CH2:11]2)(=[O:23])=[O:22])=[CH:25][CH:26]=1)#[N:31]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 685191317-{2-[(4-Cyano-benzenesulfonyl)-methyl-amino]-ethyl}-9-oxa-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester

Product 1

HCID 131727850HCID 131727850, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Step (iii) product 7-{2-[(4-Cyano-benzenesulfonyl)-methyl-amino]-ethyl}-9-oxa-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (2.2 g) was dissolved in dioxane (10 ml) and to which HCl in dioxane (saturated, 20 ml) was added drop by drop at RT under nitrogen atmosphere. Solvent was decanted, the precipitated solid was washed with dry diethyl ether (three times) and dried under vacuum to yield the title compound (2 g) as white powder.

Workup

  1. additionwas added drop by drop at RT under nitrogen atmosphere
  2. customSolvent was decanted
  3. washthe precipitated solid was washed with dry diethyl ether (three times)
  4. customdried under vacuum

Sources & evidence

ORD record
ord-2e0da66b289d4e6991c522be9a8c382a
Source dataset
uspto-grants-2010_01
Patent number
US07648985B2

Reaction notes

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