HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1992360Generated: October 31, 2026
Potassium Carbonate → {3-[7-(4-Cyano-benzyl)-9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl]-propyl}-carbamic acid tert-butyl ester
https://huagongshe.com/reaction/1992360
Participants
| Role | Name | HCID | Charge |
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| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-butyl N-(3-bromopropyl)carbamate | HCID 4460490 | — |
| Reactant | 4-(9-Oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl-methyl)-benzonitrile hydrochloride | HCID 67096696 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | {3-[7-(4-Cyano-benzyl)-9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl]-propyl}-carbamic acid tert-butyl ester | HCID 15980222 | 110.2% |
Reaction Steps
A suspension of 4-(9-Oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl-methyl)-benzonitrile hydrochloride (6.8 g, 0.021 mol; from step (ii) above), (3-Bromopropyl)-carbamic acid tert-butyl ester (3.93 g, 0.017 mol) and dry K2CO3 (8.24 g, 0.059 mol) in 27 ml of dry acetonitrile was stirred at 60° C. overnight under N2 atmosphere. The reaction mixture was filtered through celite and filtrate was concentrated under reduced pressure to give (7.5 g) of the sub-title compound as pale a liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07648985B2 |
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| Source dataset | uspto-grants-2010_01 |
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| ORD ID | ord-222e9850e0504135a7de85d18e446f66 |
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| Source note | uspto-grants-2010_01 |
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