Methyl iodide → 4-Bromo-2-fluoroanisole

Participants

Reaction Steps

Methyl iodide (182.1 ml, 1.319 mol) was added at 0° C. to a well stirred suspension of 4-bromo-2-fluorophenol (210 g, 1.099 mol, from step (i) above ) and K2CO3 (303.92 g, 2.19 mol) in dry acetone (1.7 L) and stirring continued at 60° C. for two days under nitrogen atmosphere. The reaction mixture was filtered and the solvent was concentrated under reduced pressure to yield 4-bromo-2-fluoro-anisole (225 g) as a liquid. This was directly taken for next step without further purification.

Provenance & Evidence