Potassium Carbonate → AZD1305

Participants

Reaction Conditions

Reaction Steps

A suspension of intermediate 3-fluoro-4-[2-(9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl)-ethoxy]-benzonitrile hydrochloride (5 g, 0.0137 mol, from step (vii) above), and tert-butyl 2-bromoethylcarbamate (3.98 g, 0.0178 mol , see WO 01/28992) and potassium carbonate (7.57 g, 0.0548 mol) in dry acetonitrile (100 ml) was stirred at 60° C. overnight under nitrogen atmosphere. The reaction mixture was filtered through celite and filtrate was concentrated under reduced pressure. The residue was purified by column chromatography over silica gel using 5% methanol in dichloromethane as eluent to give the sub-title compound (4.6 g) as an oil.

Provenance & Evidence