Hydrochloric Acid → HCID 68523591, compound

Participants

Reaction Steps

4-{2-[7-(3-Amino-propyl)-9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl]-ethoxy}-3-fluoro-benzonitrile TFA-salt (7.79 g, 11.3 mmol, from step (iii) above) was dissolved in dioxane (15 ml). HCl (14 ml of a 4M solution in dioxane was added. The HCl-salt precipitated, the dioxane was decanted off and to the solid was added dioxane (10 ml ) followed by HCl (4 ml in dioxane). The solvent was decanted off and the solid was dried under vacuum. The solid was dissolved in water (5 ml) and freeze dried giving 2.98 g of the title compound

Provenance & Evidence