反应详情

NaBH4 (1.46 g, 0.038 mol) was added at 0° C. to a solution (3,4-difluoro-phenyl)-acetaldehyde (5.5 g 0.35 mol, from step (ii) above) in 90 ml ethanol and stirred at RT overnight. The solvent was evaporated under reduced pressure and the residue was partitioned between 50 ml of 1 N HCl and 50 ml of diethylether. Organic layer was washed with water, dried over sodium sulfate and solvent evaporated under reduced pressure to give (5.5 g) of the sub-title compound as a liquid. This was directly taken for next step without further purification.

1. customThe solvent was evaporated under reduced pressure
2. customthe residue was partitioned between 50 ml of 1 N HCl and 50 ml of diethylether
3. washOrganic layer was washed with water
4. dry with materialdried over sodium sulfate and solvent
5. customevaporated under reduced pressure