反应详情

NaBH4 (2 g, 0.055 mol) was added at 0° C. to a solution of 4-trifluoromethyl-phenyl)-acetaldehyde (9.4 g, 0.05 mol, from step (ii) above) in 154 ml ethanol and stirred at RT overnight. The solvent was evaporated under reduced pressure and the residue was partitioned between 50 ml 1 N HCl and 50 ml diethyl ether. Organic layer was washed with water, dried over sodium sulfate and the solvent evaporated under reduced pressure to give 10 g of the sub-title compound as a liquid. This was directly taken for next step without further purification.

1. customThe solvent was evaporated under reduced pressure
2. customthe residue was partitioned between 50 ml 1 N HCl and 50 ml diethyl ether
3. washOrganic layer was washed with water
4. dry with materialdried over sodium sulfate
5. customthe solvent evaporated under reduced pressure