Formic Acid → HCID 131727852, compound

Participants

Reaction Steps

A saturated solution of HCl in ethyl acetate (200 mL) was added to an ice-cooled slurry of the acetic and formic acid salt of tert-butyl {2-[7-(4-cyanobenzyl)-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]ethyl}carbamate (7.00 g, 14.2 mmol). The reaction mixture was stirred at room temperature for 3 hours after which it was filtered and the resultant solid was washed with ethyl acetate. Drying in vacuo gave 6.12 g (96%) of the title compound with one equivalent of residual ethyl acetate.

Provenance & Evidence